To take this one more tiny step, if you do get an agent in one country, but also want to try publishing in a different country, do you tell the first agent that you're looking for an agent in a different country in order to widen your audience? Or, is it better from the beginning to find one agent who is global? If such a person exists.
Or, once the book has landed at a publisher, does the publisher release it in different countries?
Now that I've typed this, I suspect the answer may be "It depends."
I read somewhere that U.S. (where I live) audiences prefer unambiguous endings and don't go for books on the darker side. Bows must be tied, bad guys must be caught, justice must be handed down, etc. I know that was just one set of market research and a generalization but I don't fit into that category as a reader and not all the sub-plots in my book will be neatly wrapped up at the end (as I'm planning a series). Because of that I have in my mind that my U.S. audience will be limited (that is, of course, if anyone even wants to read something I write).